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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
Phentermine (phenyl-tertiary-butyl amine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat obesity. It is taken by mouth for up to a few weeks at a time, after which the benefits subside. [3]
Fastin is a dietary supplement that is manufactured and marketed for weight loss by Hi Tech Pharmaceuticals in Atlanta, GA. There is no clinical evidence that this supplement is effective for weight loss. [1] Fastin was once a brand name of a drug called phentermine and the Fastin brand of phentermine was manufactured by King Pharmaceuticals.
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Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
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Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.
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