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In biochemistry and medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin α IIb β 3) is an integrin complex found on platelets. It is a transmembrane receptor for fibrinogen [1] and von Willebrand factor, and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in ...
Integrins couple the cell- extracellular matrix (ECM) outside a cell to the cytoskeleton (in particular, the microfilaments) inside the cell. Which ligand in the ECM the integrin can bind to is defined by which α and β subunits the integrin is made of. Among the ligands of integrins are fibronectin, vitronectin, collagen, and laminin.
Integrin beta 2. In molecular biology, CD18 ( Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [ 5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as ...
Leukocyte adhesion deficiency ( LAD) is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. [ 1] LAD is currently divided into three subtypes: LAD1, LAD2, and the recently described LAD3, also known as LAD-1/variant. In LAD3, the immune defects are supplemented by a Glanzmann thrombasthenia ...
Glanzmann's thrombasthenia is associated with abnormal integrin α IIb β 3, formerly known as glycoprotein IIb/IIIa (GpIIb/IIIa), [ 7] which is an integrin aggregation receptor on platelets. This receptor is activated when the platelet is stimulated by ADP, epinephrine, collagen, or thrombin. GpIIb/IIIa is essential to blood coagulation since ...
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell ...
It also relies upon Microsoft-specific technologies such as ASP.NET, a decision that locks them out of OSX and Linux, both platforms on which Second Life runs. As a chat client, METAbolt doesn't ...
Integrin alpha X. CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) ( ITGAX ), is a gene that encodes for CD11c . [ 5][ 6] CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain ...