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In biochemistry and medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin α IIb β 3) is an integrin complex found on platelets. It is a transmembrane receptor for fibrinogen [1] and von Willebrand factor, and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in ...
Integrins couple the cell- extracellular matrix (ECM) outside a cell to the cytoskeleton (in particular, the microfilaments) inside the cell. Which ligand in the ECM the integrin can bind to is defined by which α and β subunits the integrin is made of. Among the ligands of integrins are fibronectin, vitronectin, collagen, and laminin.
Leukocyte adhesion deficiency ( LAD) is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. [ 1] LAD is currently divided into three subtypes: LAD1, LAD2, and the recently described LAD3, also known as LAD-1/variant. In LAD3, the immune defects are supplemented by a Glanzmann thrombasthenia ...
Integrin beta 2. In molecular biology, CD18 ( Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [ 5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as ...
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell ...
A Brief Guide to Imprudence 1.2. Imprudence 1.2 adds many new features, fixes, and improvements to the viewer experience. Here are a just few of the new features and improvements since Imprudence ...
Lymphocyte function-associated antigen 1 ( LFA-1) is an integrin found on lymphocytes and other leukocytes. [ 1] LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes. [ 2] Additionally, LFA-1 is involved in the process of ...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene. [5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling.