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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Studies have shown that lipase inhibitors work optimally when 40% of an individual's daily caloric intake is obtained from fat. [1] [clarification needed] Orlistat tends to block absorption of 30% of total fat intake from a meal, as orlistat passes out of the digestive tract more rapidly than fat does. [2]
[5] [8] [9] For that reason orlistat was chosen over lipstatin for development as an anti-obesity drug. [1] [10] It is the only available FDA-approved oral lipase inhibitor and is known on the market as Xenical and Alli. [5] Initially orlistat was developed as a treatment for dyslipidemia, not as an anti-obesity agent. When researchers found ...
After Oprah Winfrey confirmed she’s taking a weight-loss drug as part of her regimen to stay healthy, questions began about how exactly she’s using the medication. Winfrey didn’t specify ...
For example, a 2017 study looked at 73 women with obesity who either took 1000mg of metformin or 360mg of orlistat — another weight loss medication — for three months. Although the group ...
Wegovy, the brand name used for Semaglutide, is a weight loss drug developed and owned by Novo Nordisk. Semaglutide works in terms of weight loss by suppressing a person appetite. The drug has ...
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