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Metoprolol is a beta blocker, or an antagonist of the β-adrenergic receptors. It is specifically a selective antagonist of the β 1 -adrenergic receptor and has no intrinsic sympathomimetic activity. [ 37] Metoprolol exerts its effects by blocking the action of certain neurotransmitters, specifically adrenaline and noradrenaline.
Beta blocker. Skeletal formula of propranolol, the first clinically successful beta blocker. Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms ( arrhythmia ), and to protect the heart from a second heart attack after a first heart attack ( secondary prevention ). [ 1]
Bisoprolol. Bisoprolol, sold under the brand name Zebeta among others, is a beta blocker which is selective for the beta-1 receptor [ 7] and used for cardiovascular diseases, [ 7] including tachyarrhythmias, high blood pressure, angina, and heart failure. [ 7][ 8] It is taken by mouth. [ 7]
Figure 1: The chemical structure of dichloroisoprenaline or dichloroisoproterenol (), abbreviated DCI — the first β-blocker to be developed. β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. [1]
Class II agents are conventional beta blockers. They act by blocking the effects of catecholamines at the β 1-adrenergic receptors, thereby decreasing sympathetic activity on the heart, which reduces intracellular cAMP levels and hence reduces Ca 2+ influx. These agents are particularly useful in the treatment of supraventricular tachycardias.
Beta-blockers can block beta-1 adrenergic receptors and/or beta-2 adrenergic receptors. Those that block beta-1-adrenergic receptors prevent the binding of endogenous catecholamines (such as epinephrine and norepinephrine), which ultimately reduces blood pressure through decreasing renin and cardiac output release.
Labetalol is a beta blocker, or an antagonist of the β-adrenergic receptors. It is specifically a non-selective antagonist of the β 1 - and β 2 -adrenergic receptors. [ 17] Labetalol has intrinsic sympathomimetic activity. [ 17] It is also an antagonist of the α 1 -adrenergic receptor, and hence is additionally an alpha blocker.
Adrenergic neuron blockers. Adrenergic neurone blockers, commonly known as adrenergic antagonists, are a group of drugs that inhibit the sympathetic nervous system by blocking the activity of adrenergic neurones. They prevent the action or release of catecholamines such as norepinephrine and epinephrine. They are located throughout the body ...
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