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In the I-E system of E. coli Cas1 and Cas2 form a complex where a Cas2 dimer bridges two Cas1 dimers. [115] In this complex Cas2 performs a non-enzymatic scaffolding role, [ 115 ] binding double-stranded fragments of invading DNA, while Cas1 binds the single-stranded flanks of the DNA and catalyses their integration into CRISPR arrays.
The QR code system was invented in 1994, at the Denso Wave automotive products company, in Japan. [6] [7] [8] The initial alternating-square design presented by the team of researchers, headed by Masahiro Hara, was influenced by the black counters and the white counters played on a Go board; [9] the pattern of position detection was found and determined by applying the least-used ratio (1:1:3 ...
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