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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Examples of such medications include the Orlistat, which was first prescribed in 1998. In 2009, it became an over-the-counter drug after obtaining consent from the European Medicines Agency . In clinical trials, patients prescribed with Orlistat (120 mg) showed better weight loss than those without (8.76 kg vs 5.81 kg) in one year. [14]
It is a selective and potent irreversible inhibitor of human gastric and pancreatic lipases. Tetrahydrolipstatin, more commonly known as orlistat, is a saturated derivative produced by hydrogenation. It was developed in 1983 by Hoffmann-La Roche and is a more simple and stable compound than lipstatin.
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
Wed, Jun 5, 2024 ยท 2 min read. SOPA Images via Getty Images. Australia's independent regulator for online safety has ended its bid to remove a violent video from X (formerly Twitter). On April 15 ...
e. Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of ...
Loratadine. Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [ 5] This includes allergic rhinitis (hay fever) and hives. [ 5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. [ 5]
Raloxifene. Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. [ 5] For osteoporosis it is less preferred than bisphosphonates. [ 5] It is also used to reduce the risk of breast cancer in those at high risk. [ 5]