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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Figure 1: During fat digestion, lipases in the gastrointestinal tract hydrolyse fat ( triglycerides) into smaller molecules ( free fatty acids and monoglycerides) which can be absorbed through the duodenal mucosa. Lipase inhibitors bind to lipases and inactivate the enzyme. That leads to excretion of the undigested fat with faeces.
e. Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of ...
Orlistat (Xenical, Alli). Orlistat works by preventing your body from absorbing dietary fats. It inhibits lipase, an enzyme in the intestine that breaks down fat molecules. This leads to reduced ...
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Dr. Robert Lufkin says he taught lies in medical school about weight loss, diet, high blood pressure, and statins to prevent heart disease. Experts respond.
Sibutramine is a serotonin–norepinephrine reuptake inhibitor (SNRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%), [ 22] thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to ...
The twice-yearly injection of the drug lenacapavir can provide total protection against HIV infections, demonstrating 100% efficacy in Phase 3 trial data released by drugmaker Gilead and published ...
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