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C-reactive protein. C-reactive protein ( CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.
In contrast, C-reactive protein (with a half-life of 6–8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. For example, in active systemic lupus erythematosus, one may find a raised ESR but normal C-reactive protein. [citation needed] They may also indicate liver failure. [11]
On-board diagnostics. Various views of a "MaxScan OE509" – a fairly typical onboard diagnostics (OBD) scanner, 2015. On-board diagnostics ( OBD) is a term referring to a vehicle's self-diagnostic and reporting capability. In the United States, this capability is a requirement to comply with federal emissions standards to detect failures that ...
20219 Ensembl ENSG00000132703 ENSMUSG00000026542 UniProt P02743 P12246 RefSeq (mRNA) NM_001639 NM_011318 RefSeq (protein) NP_001630 NP_035448 Location (UCSC) Chr 1: 159.59 – 159.59 Mb Chr 1: 172.72 – 172.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein ...
The cytokine Interleukin 6 and C-reactive protein are common inflammatory markers used to diagnose systemic inflammation risk. [3] Baseline C-reactive protein levels deviate due to natural genetic variation, but significant increases can result from risk factors such as smoking, obesity, lifestyle, and high blood pressure. [3]
Rheumatoid arthritis ( RA) is a long-term autoimmune disorder that primarily affects joints. [ 1] It typically results in warm, swollen, and painful joints. [ 1] Pain and stiffness often worsen following rest. [ 1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [ 1]
AA amyloidosis is a form of amyloidosis, a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of various tissues and organs. In AA amyloidosis, the deposited protein is serum amyloid A protein (SAA), an acute-phase protein which is normally soluble and whose plasma concentration is highest ...
D001797. [ edit on Wikidata] Schematic representation of a protein electrophoresis gel. Serum protein electrophoresis ( SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [ 1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma, a ...