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A scale-free network is a network whose degree distribution follows a power law, at least asymptotically. That is, the fraction P ( k) of nodes in the network having k connections to other nodes goes for large values of k as. where is a parameter whose value is typically in the range (wherein the second moment ( scale parameter) of is infinite ...
In the late 2000's, scale-free and small-world networks began shaping the emergence of systems biology, network biology, and network medicine. In 2014, graph theoretical methods were used by Frank Emmert-Streib to analyze biological networks.
A gene (or genetic) regulatory network ( GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures ...
Weighted correlation network analysis, also known as weighted gene co-expression network analysis (WGCNA), is a widely used data mining method especially for studying biological networks based on pairwise correlations between variables. While it can be applied to most high-dimensional data sets, it has been most widely used in genomic applications.
To the right is the long tail, and to the left are the few that dominate (also known as the 80–20 rule ). In statistics, a power law is a functional relationship between two quantities, where a relative change in one quantity results in a relative change in the other quantity proportional to a power of the change, independent of the initial ...
Network science. Hierarchical network models are iterative algorithms for creating networks which are able to reproduce the unique properties of the scale-free topology and the high clustering of the nodes at the same time. These characteristics are widely observed in nature, from biology to language to some social networks .
A gene co-expression network (GCN) is an undirected graph, where each node corresponds to a gene, and a pair of nodes is connected with an edge if there is a significant co-expression relationship between them. [ 1] Having gene expression profiles of a number of genes for several samples or experimental conditions, a gene co-expression network ...
Network science. In the context of network theory, a complex network is a graph (network) with non-trivial topological features—features that do not occur in simple networks such as lattices or random graphs but often occur in networks representing real systems. The study of complex networks is a young and active area of scientific research ...