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Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) in a standard regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim only to prolong life or ...
Chemotherapy regimen. A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy. The majority of drugs used in cancer chemotherapy are ...
The beginnings of the modern era of cancer chemotherapy can be traced directly to the German introduction of chemical warfare during World War I. Among the chemical agents used, mustard gas was particularly devastating. Although banned by the Geneva Protocol in 1925, the advent of World War II caused concerns over the possible re-introduction ...
VAMP regimen or VAMP chemotherapy is a four-drug combination chemotherapy regimen, used today in the treatment of Hodgkin lymphoma. [1] [2] It was one of the earliest combination chemotherapy regimens, originally developed as a treatment for childhood leukemia by a group of researchers at the National Cancer Institute led by Emil Frei and Emil Freireich.
FLAG is a chemotherapy regimen used for relapsed and refractory acute myeloid leukemia (AML). [ 1] The acronym incorporates the three primary ingredients of the regimen: Fl udarabine: an antimetabolite that, while not active toward AML, increases formation of an active cytarabine metabolite, ara-CTP, in AML cells; A rabinofuranosyl cytidine (or ...
Cytarabine. Cytarabine, also known as cytosine arabinoside ( ara-C ), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. [ 2] It is given by injection into a vein, under the skin, or into the cerebrospinal fluid. [ 2]
1942 – First chemotherapy drug mustine used to treat cancer [11] 1947 – American Dr. Sidney Farber induces brief remission in a patient with leukaemia with the antifolate drug aminopterin (methotrexate) [4] 1949 – US FDA approves mechlorethamine, a nitrogen mustard compound, for treatment of cancer [12]
The U.S. Food and Drug Administration (FDA) has approved imatinib as first-line treatment for Philadelphia chromosome-positive CML, both in adults and children. The drug is approved in multiple contexts of Philadelphia chromosome-positive CML, including after stem cell transplant, in blast crisis, and newly diagnosed. [11]
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