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Asthma is a long-term inflammatory disease of the airways of the lungs. [ 4] It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. [ 9][ 10] Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. [ 3]
In 1890 adrenalin was first given to asthma patients orally. It had little or no effect because it is metabolized in the digestive tract and is deactivated. In 1930 epinephrine was for the first time given subcutaneously and was discovered to have a positive effect on asthma. [ 1 ]
In 1903 adrenaline, meanwhile purified, was first used in asthma. The use was based, not on the bronchodilator effect, which was discovered later, [15] [16] but on the vasoconstrictor effect, which was hoped to alleviate the “turgidity of the bronchial mucosa” – presumably vascular congestion and edema. [17]
Respiratory syncytial virus (RSV) was discovered in 1956 from a laboratory chimpanzee with upper respiratory tract disease. When 14 chimpanzees were observed with cold-like symptoms, Morris and colleagues discovered a new virus they initially named the "chimpanzee coryza agent" (CCA).
Salbutamol. Salbutamol, also known as albuterol and sold under the brand name Ventolin among others, [ 1] is a medication that opens up the medium and large airways in the lungs. [ 8] It is a short-acting β 2 adrenergic receptor agonist that causes relaxation of airway smooth muscle. [ 8] It is used to treat asthma, including asthma attacks ...
This study was a retrospective, case-control study that compared smoking habits of 684 individuals with bronchogenic carcinoma to those without the condition. [12] The survey included questions about smoking: starting age, 20 year tobacco consumption, brands used; as well as inquires about exposure to hazardous agents in the workplace, alcohol use, and causes of death for family members.
The Asthma Research Council was started in 1927. At that time the annual income was between £1,000 and £4,000 a year. One of the first donations was used to pay for special asthma clinics at Guy's Hospital and Great Ormond Street Hospital. In 1989 it became the National Asthma Campaign and in 2004, when support for people with asthma had ...
In 1847, Scottish obstetrician James Young Simpson (1811–1870) of Edinburgh was the first to use chloroform as a general anesthetic on a human ( Robert Mortimer Glover had written on this possibility in 1842 but only used it on dogs). The use of chloroform anesthesia expanded rapidly thereafter in Europe.
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