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Prostate cancer is a major topic of ongoing research. From 2016–2020, over $1.26 billion was invested in prostate cancer research, representing around 5% of global cancer research funds. This places prostate cancer 10th among 18 common cancer types in funding per cancer death, and 9th in funding per disability-adjusted life year lost.
The prostate is a gland of the male reproductive system. In adults, it is about the size of a walnut, [3] and has an average weight of about 11 grams, usually ranging between 7 and 16 grams. [4] The prostate is located in the pelvis. It sits below the urinary bladder and surrounds the urethra.
For prostate cancer, cell morphology is graded based on the Gleason grading system. [citation needed] Of note, this system of describing tumors as "well-", "moderately-", and "poorly-" differentiated based on Gleason score of 2–4, 5–6, and 7–10, respectively, persists in SEER and other databases but is generally outdated. In recent years ...
Urology. High-grade prostatic intraepithelial neoplasia ( HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer ). [1] [2] It may be referred to simply as prostatic intraepithelial neoplasia ( PIN ). It is considered to be a pre-malignancy, or ...
Prostate cancer screening. Prostate cancer screening is the screening process used to detect undiagnosed prostate cancer in men without signs or symptoms. [1] [2] When abnormal prostate tissue or cancer is found early, it may be easier to treat and cure, but it is unclear if early detection reduces mortality rates. [2]
Signs and Symptoms. Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Cancer can be difficult to diagnose because its signs and symptoms are often nonspecific, meaning they may be general phenomena that do not point directly to a specific disease process.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
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