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The PKD Foundation is a United States non-profit organization that funds research into polycystic kidney disease (PKD). It is the second-largest U.S.-based funder of PKD research after the National Institutes of Health. Founded in 1982 by Joseph H. Bruening and Jared J. Grantham, the PKD Foundation is headquartered in Kansas City, Missouri.
Medical genetics. Autosomal dominant polycystic kidney disease ( ADPKD) is one of the most common, life-threatening inherited human disorders and the most common hereditary kidney disease. [1] [2] It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and ...
Polycystic kidney disease ( PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder [5] [6] in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. [7] These cysts may begin to develop in utero, in infancy, in childhood, or in adulthood. [8]
Kadmon Corporation, LLC. Kadmon Corporation (originally Kadmon Pharmaceuticals) is a biopharmaceutical company based in New York City. It also has operations in Warrendale, PA and Brighton, MA. The company was founded in 2009 by Samuel D. Waksal, [2] [3] founder and former CEO of ImClone Systems, now fully merged into Eli Lilly and Company.
Paroxysmal kinesigenic choreoathetosis ( PKC) also called paroxysmal kinesigenic dyskinesia ( PKD) is a rare hyperkinetic movement disorder characterized by attacks of involuntary movements, which are triggered by sudden voluntary movements. The number of attacks can increase during puberty and decrease in a person's 20s to 30s.
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Polycystin 1. Polycystin 1 ( PC1) is a protein that in humans is encoded by the PKD1 gene. [5] [6] Mutations of PKD1 are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys characterised by the development of renal cysts and severe kidney dysfunction. [7]
PKD (Polycystic Kidney Disease) domain was first identified in the polycystic kidney disease protein, polycystin-1 ( PKD1 gene), and contains an Ig-like fold consisting of a beta-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands. [1] Polycystin-1 is a large cell-surface glycoprotein ...