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Endocrinology. Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans (GAGs). These long chains of sugar carbohydrates occur within the cells that help build bone, cartilage, tendons, corneas, skin and connective tissue.
Mucopolysaccharidosis type I is a spectrum of diseases in the mucopolysaccharidosis family. It results in the buildup of glycosaminoglycans (or GAGs, or mucopolysaccharides) due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of GAGs in lysosomes. Without this enzyme, a buildup of dermatan sulfate and heparan ...
Feline disease refers to infections or illnesses that affect cats. They may cause symptoms, sickness or the death of the animal. Some diseases are symptomatic in one cat but asymptomatic in others. Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses.
Maroteaux–Lamy syndrome, or Mucopolysaccharidosis Type VI (MPS-VI), is an inherited disease caused by a deficiency in the enzyme arylsulfatase B (ARSB). [ 3] ASRB is responsible for the breakdown of large sugar molecules called glycosaminoglycans (GAGs, also known as mucopolysaccharides). In particular, ARSB breaks down dermatan sulfate and ...
Sanfilippo syndrome, also known as mucopolysaccharidosis type III (MPS III), is a rare genetic disease that mainly affects the brain and spinal cord. It is caused by a problem with how the body breaks down certain large sugar molecules called glycosaminoglycans (also known as GAGs or mucopolysaccharides). In children with this condition, these ...
1 in 100,000 to 150,000 male births [ 1] Hunter syndrome, or mucopolysaccharidosis type II ( MPS II ), is a rare genetic disorder in which large sugar molecules called glycosaminoglycans (or GAGs or mucopolysaccharides) build up in body tissues. It is a form of lysosomal storage disease. Hunter syndrome is caused by a deficiency of the ...
Frequency. 1 in 100,000. Hurler syndrome, also known as mucopolysaccharidosis Type IH ( MPS-IH ), Hurler's disease, and formerly gargoylism, is a genetic disorder that results in the buildup of large sugar molecules called glycosaminoglycans (GAGs) in lysosomes. The inability to break down these molecules results in a wide variety of symptoms ...
The first theory suggests feline hyperesthesia syndrome is a behavioural disorder, which is caused by either behavioural displacement or stress factors. Stress increases the release of [alpha]-melanocyte-stimulating hormone and causes increased grooming and endorphin production. [ 2][ 4][ 5][ 6] Behavioural displacement would occur when a cat ...
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