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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Therefore, it is recommended to take a multiple-vitamin supplement during orlistat therapy. [9] [12] Cetilistat, a new lipase inhibitor, is an experimental drug for obesity. In October 2016 the drug was still in clinical trials. [13] Cetilistat was developed to overcome the adverse effects on the gastrointestinal tract of orlistat.
Studies have shown that lipase inhibitors work optimally when 40% of an individual's daily caloric intake is obtained from fat. [ 1 ] [ clarification needed ] Orlistat tends to block absorption of 30% of total fat intake from a meal, as orlistat passes out of the digestive tract more rapidly than fat does.
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Orlistat (Xenical, Alli). Orlistat works by preventing your body from absorbing dietary fats. It inhibits lipase, an enzyme in the intestine that breaks down fat molecules. This leads to reduced ...
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