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Phentermine (phenyl-tertiary-butyl amine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat obesity. [3] It is taken by mouth for up to a few weeks at a time, after which the benefits subside. [ 3 ]
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Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl- N -ethylamphetamine. [8] It is a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [8] Some analogues of fenfluramine include norfenfluramine, benfluorex, flucetorex, and fludorex.
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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.