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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Orlistat inhibits FAS with the same mechanism as it does with pancreatic lipase, that is by binding covalently to the active serine site. [35] This effect of orlistat as a FAS-inhibitor was first identified in a high throughput screening for enzymes with prostate cancer inhibition activity. However FAS is resistant to many cancer medicines.
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested ...
Here’s the TL;DR on metformin and weight loss: It may take weeks or months to see weight loss on metformin . Research shows people lose weight after three to six months of treatment. But don’t ...
Oily stool, a.k.a. steatorrhea. Steatorrhea refers to bulky, foul-smelling, oily stool that tends to be pale in color and float in the toilet bowl, resisting flushing. (These are the 9 most common ...
Because minoxidil is a widely used, thoroughly tested medication, its side effects are well known among healthcare providers and researchers. Depending on the formulation, the most common topical ...
Lipase inhibitors can be found naturally in plants and can also be produced as pharmaceutical drugs.Some lipase inhibitors have been identified in Panax ginseng. [5] [6] Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, Boesenbergia rotunda, apples and Morus alba also had strong effect against lipase.
Orlistat is used for weight loss in conjunction with exercise and a reduced-calorie diet, as well as after weight loss to help people keep from gaining back that weight.
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