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Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. It is a selective direct factor Xa inhibitor with an onset of action of 2.5 to 4 hours. [34] Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade , inhibiting both thrombin formation and development of thrombi.
Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse". In oncology , PFS usually refers to situations in which a tumor is present, as demonstrated by laboratory testing, radiologic testing, or clinically.
A year can also be measured by starting on any other named day of the calendar, and ending on the day before this named day in the following year. This may be termed a "year's time", but not a "calendar year". To reconcile the calendar year with the astronomical cycle (which has a fractional number of days) certain years contain extra days ...
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Calendar date. A calendar date is a reference to a particular day represented within a calendar system. The calendar date allows the specific day to be identified. The number of days between two dates may be calculated. For example, "25 July 2024" is ten days after "15 July 2024". The date of a particular event depends on the observed time zone.
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