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163 million (2017) [ 8] Major depressive disorder ( MDD ), also known as clinical depression, is a mental disorder [ 9] characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, [ 10] the term was adopted ...
Mixed anxiety–depressive disorder. Mixed anxiety–depressive disorder ( MADD) is a diagnostic category that defines patients who have both anxiety and depressive symptoms of limited and equal intensity accompanied by at least some autonomic nervous system features. Autonomic features are involuntary physical symptoms usually caused by an ...
A major depressive episode ( MDE) is a period characterized by symptoms of major depressive disorder. Those affected primarily exhibit a depressive mood for at least two weeks or more, and a loss of interest or pleasure in everyday activities. Other symptoms can include feelings of emptiness, hopelessness, anxiety, worthlessness, guilt ...
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder [ 2] where a disturbance in the person's mood is the main underlying feature. [ 3] The classification is in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD).
The Major Depression Inventory ( MDI) is a self-report mood questionnaire developed by the World Health Organization. The instrument was constructed by a team led by Professor Per Bech, a psychiatrist based at Frederiksborg General Hospital in Denmark. [1] The MDI differs from many other self-report inventories, such as the Beck Depression ...
Self-harm, suicide. Treatment-resistant depression (TRD) is major depressive disorder in which an affected person does not respond adequately to at least two different antidepressant medications at an adequate dose and for an adequate duration. [1] Inadequate response has most commonly been defined as less than 25% reduction in depressive ...
The International Classification of Diseases (ICD) is an international standard diagnostic classification for a wide variety of health conditions. The ICD-10 states that mental disorder is "not an exact term", although is generally used "...to imply the existence of a clinically recognisable set of symptoms or behaviours associated in most cases with distress and with interference with ...
In the mid-20th century, researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [ 32]