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Tylenol (/ ˈtaɪlənɒl /) is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol (known in the United States, Canada, and various other countries as acetaminophen), an analgesic ...
Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
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On September 28, 1982, 12-year-old Mary Kellerman was hospitalized after consuming a capsule of Extra-Strength Tylenol; she died the next day. [1] [2] On September 29, six other individuals consumed contaminated Tylenol, [1] including Adam Janus (27), Stanley Janus (25), and Theresa Janus (20), who each took Tylenol from a single bottle.
Paracetamol's bioavailability is dose-dependent: it increases from 63% for 500 mg dose to 89% for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 134 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21%. [ 6 ]
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