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392 million (2015) [ 11] Type 2 diabetes ( T2D ), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [ 6] Common symptoms include increased thirst, frequent urination, fatigue and unexplained weight loss. [ 3]
4.2 million (2019) [ 9] Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [ 10][ 11] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [ 12]
Frequency. Relatively common [ 2] Hyperosmolar hyperglycemic state ( HHS ), also known as hyperosmolar non-ketotic state ( HONK ), is a complication of diabetes mellitus in which high blood sugar results in high osmolarity without significant ketoacidosis. [ 4][ 5] Symptoms include signs of dehydration, weakness, leg cramps, vision problems ...
The leading cause of hyperglycemia in type 2 diabetes is the failure of insulin to suppress glucose production by glycolysis and gluconeogenesis due to insulin resistance. [24] Insulin normally inhibits glycogenolysis, but fails to do so in a condition of insulin resistance, resulting in increased glucose production. [ 25 ]
While obesity is an independent risk factor for type 2 diabetes that may be linked to lifestyle, obesity is also a trait that may be strongly inherited. [21] [22] Other research also shows that type 2 diabetes can cause obesity as an effect of the changes in metabolism and other deranged cell behavior attendant on insulin resistance. [23]
Diabetic nephropathy, also known as diabetic kidney disease, [ 5] is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. The triad of protein leaking into the urine (proteinuria or albuminuria ...
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