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Dopaminergic pathways ( dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [ 1] Each pathway is a set of projection neurons, consisting of individual dopaminergic neurons.
The dopaminergic cell groups and pathways make up the dopamine system which is neuromodulatory. Dopaminergic neurons (dopamine-producing nerve cells) are comparatively few in number—a total of around 400,000 in the human brain [40] —and their cell bodies are confined in groups to a few relatively small brain areas. [41]
The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine -releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [ 9] It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that ...
The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex. It is one of the four major dopamine pathways in the brain. It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control ...
Dopaminergic means "related to dopamine " (literally, "working on dopamine"), dopamine being a common neurotransmitter. [ 1] Dopaminergic substances or actions increase dopamine-related activity in the brain. Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT ...
Additionally, they said that semaglutide and other GLP-1 medications “regulate dopaminergic pathways underlying reward sensitivity, which are at least partly responsible for their weight-loss ...
The nigrostriatal pathway is a bilateral dopaminergic pathway in the brain that connects the substantia nigra pars compacta (SNc) in the midbrain with the dorsal striatum (i.e., the caudate nucleus and putamen) in the forebrain. It is one of the four major dopamine pathways in the brain, and is critical in the production of movement as part of ...
The ventral tegmental area ( VTA) ( tegmentum is Latin for covering ), also known as the ventral tegmental area of Tsai, [ 1] or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain. The VTA is the origin of the dopaminergic cell bodies of the mesocorticolimbic dopamine system and other ...