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Sibutramine is a serotonin–norepinephrine reuptake inhibitor (SNRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%), [ 22] thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to ...
Abbott Laboratories agreed to withdraw diet drug Meridia, after clinical trial data concluded that the drug increased the risk of heart attack and stroke and did little to help people lose weight.
Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [ 4] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [ 3][ 5] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [ 2] Reintroduced 2002 with restricted indication and ...
In 1997, the FDA approved the weight loss drug Meridia (sibutramine hydrochloride monohydrate). But Meridia lost the FDA's blessing when clinical trial data linked the drug to an increased risk of ...
t. e. Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes ...
A Broward health company’s weight loss pill caught the attention of the FDA after the regulatory agency found it contained a drug that was taken off the market over a decade ago for possibly ...
Drug and medical-device maker Abbott Laboratories (ABT) announced Friday that it will voluntarily withdraw its controversial obesity drug Meridia, (sibutramine) from the U.S. market at the request ...
Meridia: Obesity [15] 1997: An SNRI, which, instead of being developed for the treatment of depression, was widely marketed as an appetite suppressant for weight loss purposes. Sibutramine was the first drug for the treatment of obesity to be approved in 30 years. [16]