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The following languages are listed as having at least 50 million first-language speakers in the 27th edition of Ethnologue published in 2024. [7] This section does not include entries that Ethnologue identifies as macrolanguages encompassing all their respective varieties, such as Arabic, Lahnda, Persian, Malay, Pashto, and Chinese.
Specialty drugs or specialty pharmaceuticals are a recent designation of pharmaceuticals [1] [2] classified as high-cost, [3] [4] [5] high complexity and/or high touch. [4] Specialty drugs are often biologics [3] [6] —"drugs derived from living cells" [7] that are injectable or infused (although some are oral medications). [4]
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, [1] [2] and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
When two, highly protein-bound drugs (A and B) are added into the same biological system it will lead to an initial small increase in the concentration of free drug A (as drug B ejects some of the drug A from its proteins). However, this free drug A is now more available for redistribution into the body tissues and/or for excretion.
Louis Pasteur - pioneering stereochemist. Chirality can be traced back to 1812, when physicist Jean-Baptiste Biot found out about a phenomenon called "optical activity." [10] Louis Pasteur, a famous student of Biot's, made a series of observations that led him to suggest that the optical activity of some substances is caused by their molecular asymmetry, which makes nonsuperimposable mirror ...
Botswana established a free healthcare system that operates a system of public medical centers, with 98% of health facilities in the country run by the government. [citation needed] All citizens are entitled to be treated in taxpayer funded facilities, though a nominal fee of ~70 BWP (~US$6.60) is typically charged for public health services except for sexual reproductive health services and ...
The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. [ 3 ]
Strong and moderate CYP3A4 inducers are drugs that decrease the AUC of sensitive substrates of a given pathway where CYP3A4 is involved by ≥80 percent and ≥50 to <80 percent, respectively. [ 83 ] [ 123 ] Weak inducers decrease the AUC by ≥20 to <50 percent.