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In 1959, phentermine first received approval from the United States FDA as an appetite-suppressing drug. [17] Eventually a hydrochloride salt and a resin form became available. [17] Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18]
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 52 ] 10% [ 53 ] or 8.25 kilograms (18.2 lb) [ 54 ]
Plus, most manufacturer coupons eventually run out. This can leave you paying hefty prices out of pocket without coverage. Finally, if you drop your Medicare drug plan and re-enroll later, ...
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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed. [1]
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