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Optimer structure with non target binding groups removed for improved Optimer performance and manufacturability. Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range. [1]
Optimer Pharmaceuticals Inc (Nasdaq: OPTR) was a biopharmaceutical company, originally headquartered in San Diego, California, and later moved to Jersey City, New Jersey, United States. The company focused on developing specialty drugs to treat gastrointestinal infections and related diseases.
A hitter with a .400 on-base percentage is considered to be great [2] and rare; [3] only 61 players in MLB history with at least 3,000 career plate appearances (PA) have maintained such an OBP. Left fielder Ted Williams, who played 19 seasons for the Boston Red Sox, has the highest career on-base percentage, .4817, in MLB history. [4]
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The following table lists the top 100 career base on balls leaders in Major League Baseball history. Since 2007, Barry Bonds [ 3 ] [ 4 ] holds the record for most career walks drawn with 2,558. Rickey Henderson [ 5 ] (2,190), Babe Ruth [ 6 ] (2,062), and Ted Williams [ 7 ] (2,021) are the only other players to draw more than 2,000 walks in ...
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