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Optimer structure with non target binding groups removed for improved Optimer performance and manufacturability. Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range. [1]
Optimer Pharmaceuticals, Inc. was founded in 1998 and registered in the state of Delaware. Corporate and R&D headquarters were located in San Diego, California until 2011. CEO Michael Nientse Chang founded, funded and built the company with his wife, Tessie Mary Che, who was COO from 1998 to 2011. From 2007 to 2013, Optimer Pharmaceuticals was ...
A hitter with a .400 on-base percentage is considered to be great [2] and rare; [3] only 61 players in MLB history with at least 3,000 career plate appearances (PA) have maintained such an OBP. Left fielder Ted Williams , who played 19 seasons for the Boston Red Sox , has the highest career on-base percentage, .4817, in MLB history. [ 4 ]
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On February 6, 2018, the Trump Justice Department under Jeff Sessions subpoenaed metadata from the Apple iCloud accounts, including "customer or subscriber account information," of at least a dozen individuals associated with the House Intelligence Committee, including Democratic ranking member Adam Schiff, member Eric Swalwell, aides, and ...