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Optimer Pharmaceuticals, Inc. was founded in 1998 and registered in the state of Delaware. Corporate and R&D headquarters were located in San Diego, California until 2011. CEO Michael Nientse Chang founded, funded and built the company with his wife, Tessie Mary Che, who was COO from 1998 to 2011. From 2007 to 2013, Optimer Pharmaceuticals was ...
Optimer structure with non target binding groups removed for improved Optimer performance and manufacturability. Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range. [1]
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This is a list of National Football League (NFL) players with the most solo and combined tackles in their careers. According to Pro-Football-Reference.com, the solo tackles are counted since 1994, and the combined tackles since 1978. Randy Gradashar, Denver Broncos 2nd all-time 2,049.
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Youth career; 2009–2020: Flamengo: Senior career* Years: Team: Apps (Gls) 2020–2023: Flamengo: 86 (1) 2023– Wolverhampton Wanderers: 45 (3) International career ‡ 2024– Brazil: 8 (0) *Club domestic league appearances and goals, correct as of 19 May 2024 ‡ National team caps and goals, correct as of 6 July 2024
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