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Optimer Pharmaceuticals, Inc. was founded in 1998 and registered in the state of Delaware. Corporate and R&D headquarters were located in San Diego, California until 2011. CEO Michael Nientse Chang founded, funded and built the company with his wife, Tessie Mary Che, who was COO from 1998 to 2011. From 2007 to 2013, Optimer Pharmaceuticals was ...
Optimer structure with non target binding groups removed for improved Optimer performance and manufacturability. Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range. [1]
A hitter with a .400 on-base percentage is considered to be great [2] and rare; [3] only 61 players in MLB history with at least 3,000 career plate appearances (PA) have maintained such an OBP. Left fielder Ted Williams , who played 19 seasons for the Boston Red Sox , has the highest career on-base percentage, .4817, in MLB history. [ 4 ]
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Bernal is a youth product of CE Berga and Gimnàstic Manresa, and moved to La Masia at the age of 6 where he worked his way up their youth categories. [1] [2] On 23 June 2023, he signed his first professional contract with Barcelona until 2026. [3]