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The major histocompatibility complex ( MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules . The name of this locus comes from its discovery through the study of transplanted ...
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, macrophages, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses . The antigens presented by class II ...
HLA-A projected away from the cell surface and presenting a peptide sequence. The peptide-MHC complex presents a surface that looks like an altered self to the TCR. The surface consisting of two α helices from the MHC and a bound peptide sequence is projected away from the host cell to the T cells, whose TCRs are projected away from the T cells towards the host cells.
Peptide loading complex. The peptide-loading complex (PLC) is a short-lived, multisubunit membrane protein complex that is located in the endoplasmic reticulum (ER). It orchestrates peptide translocation and selection by major histocompatibility complex class I (MHC-I) molecules. Stable peptide-MHC I complexes are released to the cell surface ...
MHC sexual selection has been observed in the black-throated blue warbler. Major histocompatibility complex (MHC) genes code for cell surface proteins that facilitate an organism's immune response to pathogens as well as its ability to avoid attacking its own cells. These genes have maintained an unusually high level of allelic diversity ...
Membranome. 110. The immunoglobulin superfamily ( IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily based on shared structural features with immunoglobulins (also known as antibodies ...
Motor unit recruitment. General depiction of a motor unit, consisting of a motor neuron innervating a group of muscle fibers. Motor unit recruitment is the activation of additional motor units to accomplish an increase in contractile strength in a muscle. [ 1] A motor unit consists of one motor neuron and all of the muscle fibers it stimulates.
MHC class I molecules are heterodimers that consist of two polypeptide chains, α and β 2 -microglobulin (B2M). The two chains are linked noncovalently via interaction of B2M and the α 3 domain. Only the α chain is polymorphic and encoded by a HLA gene, while the B2M subunit is not polymorphic and encoded by the Beta-2 microglobulin gene.
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