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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
[5] [8] [9] For that reason orlistat was chosen over lipstatin for development as an anti-obesity drug. [1] [10] It is the only available FDA-approved oral lipase inhibitor and is known on the market as Xenical and Alli. [5] Initially orlistat was developed as a treatment for dyslipidemia, not as an anti-obesity agent. When researchers found ...
Steatorrhea. Steatorrhea. Specialty. Gastroenterology, general surgery. Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may be bulky and difficult to flush, have a pale and oily appearance, and can be especially foul-smelling. [ 1] An oily anal leakage or some level of fecal incontinence may occur.
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e. Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of ...
Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product that was first isolated from the actinobacterium Streptomyces toxytricini. [1] The popular antiobesity drug orlistat (trade names Xenical and alli) is a saturated derivative of lipstatin.
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