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In mice and rats, the LD 50 is approximately 1250 mg/kg if administered via an injection, but the oral LD 50 for rats is 3400 mg/kg. [123] [124] The LD 50 value for humans have not been established. Human clinical trials have involved total daily doses up to 1200 mg/d for 7–21 days.
Clotrimazole. Clotrimazole, sold under the brand name Lotrimin, among others, is an antifungal medication. [ 2] It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch. [ 2] It can be taken by mouth or applied as a cream to the skin or in the vagina.
Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
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The medication has been found to achieve 96.7% to 97.3% inhibition of aromatase at a dosage of 1 mg/day and 98.1% inhibition of aromatase at a dosage of 10 mg/day in humans. [ 3 ] [ 2 ] As such, 1 mg/day is considered to be the minimal dosage required to achieve maximal suppression of aromatase with anastrozole. [ 3 ]
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